Peter de Witte Selected Research

hypericin

8/2016	Differential diagnosis of gallstones by using hypericin as a fluorescent optical imaging agent.
9/2015	Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal.
2/2014	Radioiodinated hypericin: its biodistribution, necrosis avidity and therapeutic efficacy are influenced by formulation.
12/2013	An overview of translational (radio)pharmaceutical research related to certain oncological and non-oncological applications.
1/2013	Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts.
12/2012	Pretargeting of necrotic tumors with biotinylated hypericin using 123I-labeled avidin: evaluation of a two-step strategy.
1/2012	Exploring theranostic potentials of radioiodinated hypericin in rodent necrosis models.
11/2011	Influence of the vascular damaging agents DMXAA and ZD6126 on hypericin distribution and accumulation in RIF-1 tumors.
9/2011	A dual-targeting anticancer approach: soil and seed principle.
5/2007	Evaluation of tumor affinity of mono-[(123)I]iodohypericin and mono-[(123)I]iodoprotohypericin in a mouse model with a RIF-1 tumor.

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Peter de Witte Research Topics

Disease

18	Neoplasms (Cancer) 01/2017 - 09/2002
5	Necrosis 02/2014 - 09/2011
3	Epilepsy (Aura) 01/2020 - 01/2017
3	Urinary Bladder Neoplasms (Bladder Cancer) 04/2007 - 08/2004
2	Gastroenteritis 01/2021 - 01/2021
2	Cholestasis 01/2019 - 01/2019
2	Residual Neoplasm 01/2017 - 12/2013
2	Gallstones (Gallstone) 08/2016 - 12/2013
1	Cystinosis 08/2021
1	Tuberous Sclerosis (Bourneville's Disease) 01/2021
1	Microcephaly 12/2019
1	Brain Diseases (Brain Disorder) 12/2019
1	Chemical and Drug Induced Liver Injury 01/2019
1	Myoclonic Epilepsies (Myoclonic Encephalopathy) 01/2019
1	Ovarian Neoplasms (Ovarian Cancer) 09/2015
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 11/2013
1	Brain Ischemia (Cerebral Ischemia) 11/2013
1	Seizures (Absence Seizure) 11/2013
1	Body Weight (Weight, Body) 08/2013
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2013
1	Rhabdomyosarcoma 09/2011
1	Hypothermia 07/2008
1	Transitional Cell Carcinoma 08/2004
1	Carcinoma (Carcinomatosis) 08/2004

Drug/Important Bio-Agent (IBA)

14	hypericinIBA 08/2016 - 12/2003
6	Pharmaceutical PreparationsIBA 01/2021 - 08/2004
5	1-phenyl-3,3-dimethyltriazene (PDT)IBA 03/2012 - 12/2003
4	Photosensitizing Agents (Photosensitizers)IBA 04/2007 - 09/2002
3	iodohydroxybenzylpindololIBA 02/2014 - 11/2011
2	VaccinesIBA 01/2021 - 01/2021
2	Antiviral Agents (Antivirals)IBA 01/2021 - 01/2021
2	CholesterolIBA 08/2016 - 12/2013
2	Dimethyl Sulfoxide (DMSO)FDA LinkGeneric 02/2014 - 08/2013
2	fosbretabulin (combretastatin A4)IBA 01/2013 - 09/2011
2	EnzymesIBA 04/2007 - 12/2003
2	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2007 - 12/2003
1	Nonsense Codon (Nonsense Mutation)IBA 08/2021
1	Cystine (L-Cystine)IBA 08/2021
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2021
1	Amino Acids FDA Link 01/2021
1	Proteins (Proteins, Gene)FDA Link 01/2021
1	trans-sodium crocetinate (crocetin)IBA 01/2021
1	Insulin (Novolin)FDA Link 01/2021
1	magnololIBA 01/2020
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2020
1	honokiolIBA 01/2020
1	Valine-tRNA LigaseIBA 12/2019
1	Bile Acids and Salts (Bile Acids)IBA 01/2019
1	Urea (Carbamide)FDA LinkGeneric 01/2019
1	Taurocholic Acid (Sodium Taurocholate)IBA 01/2019
1	Dacarbazine (DIC)FDA LinkGeneric 01/2019
1	Member 11 Subfamily B ATP Binding Cassette TransporterIBA 01/2019
1	ChemokinesIBA 01/2017
1	Therapeutic UsesIBA 01/2017
1	NAD (NADH)IBA 01/2017
1	Purinergic Receptors (Receptors, Purine)IBA 01/2017
1	SolventsIBA 08/2016
1	Mitoxantrone (Novantrone)FDA LinkGeneric 09/2015
1	Biomarkers (Surrogate Marker)IBA 09/2015
1	Paclitaxel (Taxol)FDA LinkGeneric 09/2015
1	Biological ProductsIBA 12/2013
1	Iodine-131IBA 12/2013
1	Prescription DrugsIBA 11/2013
1	tanshinoneIBA 11/2013
1	1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenylglycolurilIBA 08/2013
1	AvidinIBA 12/2012
1	Biotin (Vitamin H)FDA Link 12/2012
1	Peptides (Polypeptides)IBA 10/2012
1	AntigensIBA 10/2012
1	Phosphatidylinositols (Phosphatidylinositol)IBA 03/2012
1	Adenosine Triphosphate (ATP)IBA 03/2012
1	Caspase 8 (Caspase-8)IBA 03/2012
1	CalreticulinIBA 03/2012
1	Dexamethasone (Maxidex)FDA LinkGeneric 11/2011
1	Trinitrotoluene (TNT)IBA 11/2011
1	N-acetylcochinol-O-phosphateIBA 11/2011
1	vadimezanIBA 11/2011
1	SolutionsIBA 09/2011
1	IodineIBA 09/2011
1	AntioxidantsIBA 04/2007
1	Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA 04/2007
1	CalciumIBA 11/2005
1	Arachidonic Acid (Vitamin F)IBA 11/2005
1	Phospholipases A2 (Phospholipase A2)IBA 11/2005
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2005
1	Oxygen (Dioxygen)IBA 08/2004
1	Dinoprostone (PGE2)FDA Link 12/2003
1	imidazoleIBA 12/2003
1	p38 Mitogen-Activated Protein KinasesIBA 12/2003
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 12/2003
1	Transferrin Receptors (Transferrin Receptor)IBA 09/2002

Therapy/Procedure

7	Therapeutics 08/2021 - 12/2003
6	Photochemotherapy (Photodynamic Therapy) 09/2015 - 12/2003
4	Radiotherapy 09/2015 - 01/2012
2	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2020 - 11/2013
2	Precision Medicine 01/2013 - 01/2012
2	Intravenous Injections 01/2013 - 05/2007
1	Immunotherapy 09/2015
1	Aftercare (After-Treatment) 09/2011
1	Anesthesia 07/2008